NIMG-89. DISSEMINATED SPINAL METASTASES FROM A PITUITARY CARCINOMA

Abstract Pituitary carcinomas are rare malignant neoplasms and rarely result in a solitary spinal metastasis. In this report we describe case of pituitary carcinoma that metastasized to the canal nerve roots at numerous levels, mimicking neurofibromatosis spine. This patient is 72 year old right-handed female with past medical history adenoma which was resected 5 years prior stable on imaging. At presentation, seen for right sciatica, an MRI showed multiple enhancing intradural extramedullary lesions mainly lumbar spine, felt represent sheath tumors, neurofibromas. She underwent genetic testing, but NF1, NF2, SMARC1B, SPRED1, LTRZ1 were not found have mutation. Over 3 period, she had progression her tumors. The lesion remained appearance. resection pathology consistent carcinoma.Patient tolerated up almost 11 full cycles temozolomide before it put hold due significant deconditioning lethargy. Imaging revealed partial response cord metastases. unusual presentation metastatic delay diagnosis resulted morbidity.